Quick Search
  Home Journal Information Current Issue Past Issues Services Contact Us  
Articles
Liver fibrosis in biliary atresia 
 
Liver fibrosis in biliary atresia
  Wen-Jun Shen, Gong Chen, Min Wang, Shan Zheng
 [Abstract] [Full Text] [PDF]   Pageviews: 631 Times
 
Background: Biliary atresia (BA) is the most common cause of obstructive jaundice in infants. Although the Kasai procedure has greatly improved the prognosis, most patients still need liver transplantation (LT) for long-term survival. The pathogenesis of BA has not been fully clarified, and liver fibrosis in BA is far beyond biliary obstructive cirrhosis.
Data sources: Literature reviews were underwent through PubMed. Persistent inflammation, immune response, biliary epithelial¨Cmesenchymal transition, matrix deposition, decompensated angiogenesis, and unique biliary structure development all contribute to the fibrosis process. Observed evidences in such fields have been collected and form the backbone of this review.
Results: Interactions of the multiple pathways accelerate this process.
Conclusions: Understanding the mechanisms of the liver fibrosis in BA may pave the way to improved survival after the Kasai procedure.
 
  [Articles Comment]

  title Author The End Revert Time Revert / Count

  Username:
  Comment Title: 
 
   

 

     
 
     
World Journal of Pediatric Surgery

roger vivier bags 美女 美女

Home  |  Journal Information  |  Current Issue  |  Past Issues  |  Journal Information  |  Contact Us
Children's Hospital, Zhejiang University School of Medicine, China
Copyright 2007  www.wjpch.com  All Rights Reserved Designed by eb