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Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic 
 
Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic
  Yue-Yue Ding, Yan Ren, Jie Qin, Guang-Hui Qian, Yun-Jia Tang, Ye Chen, Xuan Li, Lei Xu, Chun-Hong Qiao, Ling Sun, Hai-Tao Lv
 [Abstract] [Full Text] [PDF]   Pageviews: 493 Times
 
Background: The aim of this study is to explore the characteristics of Kawasaki disease (KD) and concurrent pathogens due to a stay-at-home isolation policy during coronavirus disease 2019 (COVID-19) epidemic.
Methods: All patients with KD admitted between February and April in 2015-2020, were classified into before (group 1, in 2015¨C2019) and after (group 2, in 2020) isolation groups. A total of 4742 patients [with KD (n = 98) and non-KD (n = 4644)] referred to Mycoplasma pneumoniae (MP) and virus detection were analyzed in 2020. Clinical characteristics, laboratory data, and 13 pathogens were analyzed retrospectively.
Results: Group 2 had a significantly increased incidence of KD (0.11%) with 107 patients compared to that of group 1 (0.03%) with 493 patients. The comparisons of oral mucosal change, strawberry tongue, desquamation of the fingertips, cervical lymphadenopathy and neutrophil percentage decreased in group 2 compared to group 1. The infection rate of MP increased significantly in group 2 (34.7%) compared to group 1 (19.3%), while the positive rate of viruses decreased significantly in group 2 (5.3%) compared to group 1 (14.3%). In 2020, the positive rate of MP infection increased significantly in patients with KD compared to the increase in patients with non-KD. The infection rate of MP for younger children aged less than 3 years old was higher in group 2 than in group 1.
Conclusion: Compared with the characteristics of KD from 2015 to 2019 years, the incidence of KD was increased in 2020 and was accompanied by a high incidence of MP infection, especially in younger children (less than 3 years old) during the isolation due to COVID-19 pandemic.
 
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World Journal of Pediatric Surgery

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