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Integration of multiscale entropy and BASED scale of electroencephalography after adrenocorticotropic hormone therapy predict relapse of infantile spasms 
 
Integration of multiscale entropy and BASED scale of electroencephalography after adrenocorticotropic hormone therapy predict relapse of infantile spasms
  Lin Wan, Chu-Ting Zhang, Gang Zhu, Jian Chen, Xiu-Yu Shi, Jing Wang, Li-Ping Zou, Bo Zhang, Wen-Bin Shi, Chien-Hung Yeh, Guang Yang
 [Abstract] [Full Text] [PDF]   Pageviews: 1363 Times
 
Background: Even though adrenocorticotropic hormone (ACTH) demonstrated powerful efficacy in the initially successful treatment of infantile spasms (IS), nearly half of patients have experienced a relapse. We sought to investigate whether features of electroencephalogram (EEG) predict relapse in those IS patients without structural brain abnormalities.
Methods: We retrospectively reviewed data from children with IS who achieved initial response after ACTH treatment, along with EEG recorded within the last two days of treatment. The recurrence of epileptic spasms following treatment was tracked for 12 months. Subjects were categorized as either non-relapse or relapse groups. General clinical and EEG recordings were collected, burden of amplitudes and epileptiform discharges (BASED) score and multiscale entropy (MSE) were carefully explored for cross-group comparisons.
Results: Forty-one patients were enrolled in the study, of which 26 (63.4%) experienced a relapse. The BASED score was significantly higher in the relapse group. MSE in the non-relapse group was significantly lower than the relapse group in the ¦Ã band but higher in the lower frequency range (¦Ä , ¦È , ¦Á). Sensitivity and specificity were 85.71% and 92.31%, respectively, when combining MSE in the ¦Ä/¦Ã frequency of the occipital region, plus BASED score were used to distinguish relapse from non-relapse groups.
Conclusions: BASED score and MSE of EEG after ACTH treatment could be used to predict relapse for IS patients without brain structural abnormalities. Patients with BASED score ¡Ý 3, MSE increased in higher frequency, and decreased in lower frequency had a high risk of relapse.
 
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World Journal of Pediatric Surgery

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