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Effect of early atopic sensitization in children aged 0每2 years on the development of asthma symptoms at 9每11 years of age 
 
Effect of early atopic sensitization in children aged 0每2 years on the development of asthma symptoms at 9每11 years of age
  Himmet Haluk Akar, Ebru Nadir, Burçin Beken, Yakup Yeşil
 [Abstract] [Full Text] [PDF]   Pageviews: 715 Times
 
Background: Personal genetic predisposition and early life environmental factors are important for the development of childhood asthma. We aimed to search whether egg, milk and mite sensitizations at 0每2 years old are risk factors for asthma symptoms at 9每11 years old.
Methods: A total of 210 wheezer children who had specific immunoglobulin (Ig) E in 2010每2012 were included in the study (followed by pediatric allergy). Patients were divided into non-atopic (group 1, n = 157) and atopic patients [groups 2每7, n = 53 (5 patients were in both group 4 and group 5)] based on sensitizations. Using the International Study of Asthma and Allergy in Childhood questionnaire, current wheeze (CW, 2nd question), exercise wheezing (EW, 7th question), and dry cough (DC, 8th question) were surveyed. Also, parental allergies, eczema at 0每2 years, current eosinophil percentage and total IgE were recorded.
Results: Eczema was observed as an important risk factor [CW: odds ratio (OR) = 2.83, 95% confidence interval (CI) = 1.54每5.23, P ≒ 0.001; EW: OR = 2.71, 95% CI = 1.33每5.54, P = 0.006; DC: OR = 3.03, 95% CI = 1.47每6.25, P = 0.003], whereas having no atopic sensitization at 0每2-year-old (group 1) was found as a significant protective factor for asthma at 9每11 years old (CW: OR = 0.32, 95% CI = 0.15每0.70, P = 0.004; EW: OR = 0.21, 95% CI 0.10每0.44, P ≒ 0.001; DC: OR = 0.25, 95% CI = 0.10每0.59, P = 0.002).
Conclusion: Early personal eczema is a significant risk factor for the development of asthma symptoms at 9每11 years old, whereas not having an allergic sensitization at 0每2 years old (group 1) is an important protective factor.
 
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