Quick Search
  Home Journal Information Current Issue Past Issues Services Contact Us  
Articles
Longer duration of initial invasive mechanical ventilation is still a crucial risk factor for moderate-to-severe bronchopulmonary dysplasia in very preterm infants: a multicentrer prospective study 
 
Longer duration of initial invasive mechanical ventilation is still a crucial risk factor for moderate-to-severe bronchopulmonary dysplasia in very preterm infants: a multicentrer prospective study
  Cong Dou, Yong-Hui Yu, Qing-Cui Zhuo, Jian-Hong Qi, Lei Huang, Yan-Jie Ding, De-Juan Yang, Li Li, Dan Li, Xiao-Kang Wang, Yan Wang, Xin Qiao, Xiang Zhang, Bing-Jin Zhang, Hai-Yan Jiang, Zhong-Liang Li, Simmy Reddy
 [Abstract] [Full Text] [PDF]   Pageviews: 1108 Times
 
Background: We aimed to evaluate the risk factors for moderate-to-severe bronchopulmonary dysplasia (BPD) and focus on discussing its relationship with the duration of initial invasive mechanical ventilation (IMV) in very preterm neonates less than 32 weeks of gestational age (GA).
Methods: We performed a prospective cohort study involving infants born at 23¨C31 weeks of GA who were admitted to 47 different neonatal intensive care unit (NICU) hospitals in China from January 2018 to December 2021. Patient data were obtained from the Sina-northern Neonatal Network (SNN) Database.
Results: We identified 6538 very preterm infants, of whom 49.5% (3236/6538) received initial IMV support, and 12.6% (823/6538) were diagnosed with moderate-to-severe BPD symptoms. The median duration of initial IMV in the moderateto-severe BPD group was 26 (17¨C41) days, while in the no or mild BPD group, it was 6 (3¨C10) days. The incidence rate of moderate-to-severe BPD and the median duration of initial IMV were quite different across different GAs. Multivariable logistic regression analysis showed that the onset of moderate-to-severe BPD was significantly associated with the duration of initial IMV [adjusted odds ratio (AOR): 1.97; 95% confidence interval (CI): 1.10¨C2.67], late-onset neonatal sepsis (LONS), and patent ductus arteriosus (PDA).
Conclusion: In this multicenter cohort study, the duration of initial IMV was still relatively long in very premature infants, and the longer duration of initial IMV accounts for the increased risk of moderate-to-severe BPD.
 
  [Articles Comment]

  title Author The End Revert Time Revert / Count

  Username:
  Comment Title: 
 
   

 

     
 
     
World Journal of Pediatric Surgery

roger vivier bags 美女 美女

Home  |  Journal Information  |  Current Issue  |  Past Issues  |  Journal Information  |  Contact Us
Children's Hospital, Zhejiang University School of Medicine, China
Copyright 2007  www.wjpch.com  All Rights Reserved Designed by eb