Shanghai, China

Author Affiliations: Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai 200032, China (Luo Y, Zheng S)

Corresponding Author: Shan Zheng, MD, Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai 200032, China (Tel: 86-21-54524666 ext 2042; Fax: 86-21-64038992; Email: szheng@shmu.edu.cn)

Background: Postoperative cholangitis characterized by fever and acholic stool and positive blood culture is a common and serious complication following Kasai's operation for biliary atresia. The aim of this review was to describe the pathogenesis, clinical manifestations, medical treatment and outcome of postoperative cholangitis. 

Data sources: Articles on biliary atresia retrieved from Pubmed and MEDLINE in the recent 10 years were reviewed.

Results: The pathogenesis of postoperative cholangitis is still controversial. Recent methods for the diagnosis of postoperative cholangitis include urinary sulfated bile acids (USBA) and magnetic resonance cholangio-pancreaticography (MRCP). High-dose steroids and oral antibiotics have been used to reduce the incidence of postoperative cholangitis, and recurrent cholangitis leads to a lower survival rate.

Conclusions: Cholangitis is one of the most important determinants of long-term survival after the Kasai's procedure. The knowledge on postoperative cholangitis has been increasing in the past 10 years, showing a lower incidence of the disease and better therapeutic results.

Key words: biliary atresia; cholangitis; prophylactic antibiotics

                   World J Pediatr 2008;4(1):14-19