Quick Search
  Home Journal Information Current Issue Past Issues Services Contact Us  
Articles
Efficacy and safety of measles, mumps, rubella and varicella live viral vaccines in transplant recipients receiving immunosuppressive drugs 
 
Efficacy and safety of measles, mumps, rubella and varicella live viral vaccines in transplant recipients receiving immunosuppressive drugs
  Angela Marie Danerseau, Joan Louise Robinson
 [Abstract] [Full Text] [PDF]   Pageviews: 12733 Times
   

Edmonton, Alberta, Canada

Author Affiliations: Department of Pediatrics and Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (Dansereau AM, Robinson JL)

Corresponding Author: Joan L. Robinson, Room 8213, Aberhart Centre One, 11402 University Avenue, Edmonton, AB, T6G 2J3, Canada (Tel: 780-407-1680; Fax: 780-407-7136; Email: jr3@ualberta.ca)

Background: This review was designed to summarize published data on the efficacy and safety of live viral vaccines for measles, mumps, rubella, or varicella in post-transplant patients currently on immunosuppression.

Data sources: Medline, EMBASE and Evidence Based Medicine Reviews were searched from 1966 to November 2007 for case reports or studies describing the efficacy and/or safety of live attenuated measles, mumps, rubella, or varicella vaccine in children on immunosuppression following solid organ, bone marrow or stem cell transplantation.

Results: The review identified 6 case series and 2 case reports describing 114 solid organ transplant recipients and one case series describing 27 bone marrow transplant recipients who had received a combined total of 206 doses of live varicella, measles, mumps, or rubella vaccine while on immunosuppression. Post-immunization titers were in the immune range in 109 of the 171 situations where they were measured following a single dose of vaccine (64%) and in 15 of 22 situations following 2 doses (68%). There were no major safety concerns in this small sample.

Conclusion: There are insufficient published data to derive evidence-based guidelines for use of live viral vaccines in transplant recipients on immunosuppression but preliminary data on efficacy and safety suggest that the use of these live viral vaccines in transplant recipients still on immunosuppression could be a reasonable strategy.

Key words: measles vaccine; transplantation; vaccination; varicella vaccine

                  World J Pediatr 2008;4(4):254-258

 

 

 
  [Articles Comment]

  title Author The End Revert Time Revert / Count

  Username:
  Comment Title: 
 
   

 

     
 
     
World Journal of Pediatric Surgery

roger vivier bags 美女 美女

Home  |  Journal Information  |  Current Issue  |  Past Issues  |  Journal Information  |  Contact Us
Children's Hospital, Zhejiang University School of Medicine, China
Copyright 2007  www.wjpch.com  All Rights Reserved Designed by eb