Author Affiliations: Department of Paediatrics, Kalawati Saran Children's Hospital, Lady Hardinge Medical College, New Delhi-110001, India (Mishra K, Basu S, Roychoudhury S, Kumar P)

Corresponding Author: Srikanta Basu, # 318, Ashirwad Enclave 105, I P Extension Patpargunj, New Delhi 110092, India (Tel: 0091-11-22238229/0091-9818291595; Fax: 0091-11-23365792; Email: srikantabasu@gmail.com)

doi:10.1007/s12519-010-0220-1

Background: Liver abscess (LA) in the pediatric population has become relatively uncommon in developed countries but it continues to have a high incidence among children in developing countries. This article aims to review the trends in all aspects of LA in children, both temporally and geographically.

Data sources: The PubMed and Google Scholar database were searched with the keywords "liver abscess", "children", "predisposing causes", "clinical signs and symptoms", "treatment" from 1975 to 2009 and all kinds of retrospective and prospective studies, reviews, case series were included.

Results: Pyogenic LA constitutes the majority of cases, followed by amebic and fungal LA. Staphylococcus aureus is the most common pathogen worldwide. Ultrasonography (US) and computed tomography (CT) are widely used as diagnostic tools. There are varying opinions regarding the treatment of LA in children. The general trend is towards less invasive modalities of treatment like percutaneous drainage along with antimicrobial drug therapy. However, in selected patients, open surgical drainage still plays an important role. The mortality rate for pyogenic LA has shown a decline from about 40% before the 1980s to less than 15% in the recent years. At the same time, the mortality rate of amebic LA cases reported to be around 11%-14% before 1984 has reduced to less than 1% at present.

Conclusions: Etiological pattern of LA in children has remained the same over the years, and in most regions, it is associated with Staphylococcus aureus and amebic LA is quite uncommon. US or CT scan is the most frequently employed diagnostic modality for LA, and follow-up is usually performed by serial US scans. Antimicrobial therapy along with, if necessary, drainage of the abscess by either percutaneous or open surgical route remains the treatment of choice.

Key words: children; clinical signs and symptoms; liver abscess; predisposing causes; treatment

          World J Pediatr 2010;6(3):210-216