Author Affiliations: State University of New York at Stony Brook, Stony Brook, New York 11791, USA (Shah S)

Corresponding Author: Shetal Shah, MD, FAAP, Assistant Professor of Neonatal Medicine, State University of New York at Stony Brook, Department of Pediatrics, Division of Neonatology, Health Science Center tower 11th Floor 060, Stony Brook, New York 11791, USA (Tel: 631-444-7653; Email: shetal.shah@stonybrook.edu)

doi:10.1007/s12519-010-0201-4

Background: Exogenous surfactant is currently administered via intra-tracheal instillation, a method which can increase the possibility of clinical instability in the peri-surfactant administration period. Since its introduction, there has been an increase in understanding of the pathology of respiratory distress syndrome and surfactant biology. This includes development of a potential nebulized surfactant which has the potential to increase the number, safety and timely administration of the medication in preterm infants.

Data sources: Based on recent original publications in the field of surfactant biology, we reviewed our experience with surfactant administration and discussed the available evidence on nebulized surfactant and outlined potential barriers toward widespread introduction of this therapy.

Results: Surfactant has revolutionized modern neonatal management and nebulized surfactant is attractive and a vector for administration. However, issues regarding cost-effectiveness, development of nebulizer devices capable of administration, deposition of medication in the airway and dosing strategies remain unresolved.

Conclusions: Nebulized surfactant has the potential to be a therapeutic breakthrough by eliminating the potent volu-and-baro-traumatic effects of mechanical ventilation in the peri-surfactant period. Nebulization would likely lead to increased administration immediately after birth and more emphasis on non-invasive ventilator strategies. These features will aid clinical implementation of nebulized surfactant as a standard of treatment after introduction.

Key words: nebulization; neonatal respiratory disease; surfactant

                  World J Pediatr 2011;7(1):11-15