Author Affiliations: Department of Radiology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China (Zhu JQ, Hao NX); Department of Pediatrics (Bao WQ) and Department of Pathology (Wu XR), Xin Hua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

Corresponding Author: Wei-Qun Bao, MD, Department of Pediatrics, Xin Hua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China  (Tel: 86-21-65790000 ext 8235; Email: melvine0305@sina.com)

Background: Multiple calcified primary central nervous system lymphoma (PCNSL) is extremely rare in childhood.

Methods: We report a 4-year-old boy suffering from multiple calcified B-cell lymphoma in the brain with immunodeficiency.

Results: The boy had a history of walking weakness and seizure for 4 months. The serum levels of immuno-globulin G, A and M were decreased. Brain MRI showed multiple lesions which had ring enhancement. CT showed calcification in all of the lesions. The boy was firstly misdiagnosed with multiple chronic brain abscesses. Pathological analysis of biopsy confirmed the diagnosis of anaplastic diffuse large B-cell lymphoma.

Conclusion: PCNSL should be included in the differential diagnosis of intracranial mass with calcification.

Key words: calcification; immunodeficiency; primary central nervous system lymphoma

                  World J Pediatr 2011;7(3):277-279