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Effect of thimerosal on the neurodevelopment of premature rats
Yan-Ni Chen, Jue Wang, Jie Zhang, Su-Jiao Li, Li He, Dong-Dong Shao, Hui-Ying Du
Xi'an, China
Author Affiliations: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China (Chen YN, Wang J, Li SJ); Affiliated Xi'an Children's Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710002, China (Chen YN, Zhang J, He L, Shao DD, Du HY)
Corresponding Author: Jue Wang, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China (Tel: 86-29-82663497; Fax: 86-29-82663497; Email: Juewang1@126.com).
doi: 10.1007/s12519-013-0443-z
Background: This study was undertaken to determine the effect of thimerosal on the neurodevelopment of premature rats.
Methods: Thimerosal was injected into premature SD rats at a dose of 32.8, 65.6, 98.4 or 131.2 ¦Ìg/kg on postnatal day 1. Expression of dopamine D4 receptor (DRD4) and serotonin 2A receptor (5-HT2AR), apoptosis in the prefrontal cortex on post-injection day 49, and learning and memory function were studied and compared with those in a control group injected with saline.
Results: Expression of DRD4 and 5-HT2AR and learning function decreased, and apoptosis increased significantly in the 131.2 ¦Ìg/kg group (P<0.001). Memory function was significantly impaired by 65.6 (P<0.05), 98.4 and 131.2 ¦Ìg/kg (P<0.001).
Conclusions: The negative adverse consequences on neurodevelopment observed in the present study are consistent with previous studies; this study raised serious concerns about adverse neurodevelopmental disorder such as autism in humans following the ongoing worldwide routine administration of thimerosal-containing vaccines to infants.
Key words: dopamine D4 receptor; neurodevelopment; serotonin 2A receptor; thimerosal
World J Pediatr 2013;9(4):356-360
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