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Colon carcinoma treated with oxaliplatin and capecitabine in a 12-year-old child
Dong-Lai Hu, Xiao-Dong Guo, Zhi-Nan Sun, Yan-Min Zhao
Jinhua, China
Author Affiliations: Department of Pediatric Surgery, Jinhua Hospital of Zhejiang University, Jinhua Municipal Central Hospital, Jinhua 321000, China (Hu DL, Guo XD, Sun ZN, Zhao YM)
Corresponding Author: Xiao-Dong Guo, MD, Department of Pediatric Surgery, Jinhua Hospital of Zhejiang University, Jinhua Municipal Central Hospital, Jinhua 321000, China (Tel: 86-579-82552985; Email: xewkgxd@163.com)
doi: 10.1007/s12519-014-0459-z
Background: XELOX (oxaliplatin 130mg/m2 iv, capecitabine 1000mg/m2 bid oral d1-14, q3w) chemotherapy has never been used in children. In this report, we present a case of a 12-year-old girl with colon adenocarcinoma, treated with surgery and XELOX chemotherapy.
Methods: On admission, the girl complained of abdominal pain and intestinal obstruction. Physical examination revealed a distended abdomen with tenderness on the left upper quadrant. Barium enema revealed a stenotic lesion at the distal end of the transverse colon, and abdominal computed tomography showed acute obstruction and a colonic mass. Laparotomy was performed after the failure of conservative treatment.
Results: The mass was originated from the transverse colon. Frozen sections of the specimens revealed an adenocarcinoma. Transverse colectomy was performed and regional lymph nodes were removed. Pathological examination confirmed that the mass was a poorly differentiated adenocarcinoma, and XELOX chemotherapy was used. No evidence of recurrent or metastatic tumor was found after 18 months.
Conclusion: Although complete resection is the most effective treatment, XELOX chemotherapy is beneficial to the improvement of clinical outcome of patients with colon adenocarcinoma.
Key words: chemotherapy; colon adenocarcinoma; XELOX regimen
World J Pediatr 2014;10(1):86-88
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