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Lemierre's syndrome with double heterozygote status in the methylenetetrahydrofolate reductase gene
Mostafa Behpour-Oskooee, Abdollah Karimi, Shirin Sayyahfar
Tehran, Iran
Author Affiliations: Pediatric Infectious Diseases, Department of Pediatrics, Najmieh Hospital, Baghyatollah University of Medical Sciences, Tehran, Iran (Behpour-Oskooee M); Pediatric Infectious Diseases, Pediatric Infectious Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Karimi A); Pediatric Infectious Diseases, Department of Pediatrics, Ali Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran (Sayyahfar S)
Corresponding Author: Shirin Sayyahfar, MD, Department of Pediatrics, Ali Asghar Children Hospital, Iran University of Medical Sciences, Vahid Dastgerdi Street, Shariati Street, Tehran, Iran (Tel: +98 21 22255218; Fax: +98 21 220063; Email: sayyahfar.sh@iums.ac.ir)
doi: 10.1007/s12519-014-0475-z
Background: There are some risk factors being more vulnerable to Lemierre's syndrome such as a hypercoagulable state.
Methods: We report a rare case of Lemierre's syndrome with ethmoid and maxillary sinusitis, bilateral mastoiditis, and sigmoid sinus thrombosis.
Results: Genetic study revealed a double heterozygote status in the methylenetetrahydrofolate reductase gene including C677T and A1298C.
Conclusion: It is suggested to screen patients with Lemierre's syndrome for a hypercoagulable state to consider anticoagulant therapy.
World J Pediatr 2014;10(3):281-283
Key words: Lemierre's syndrome;
mastoiditis;
methylenetetrahydrofolate reductase;
sigmoid sinus thrombosis
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