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Topical treatment with propranolol gel as a supplement to the existing treatment of hemangiomas
Markus Schneider, Andreas Reimer, Hansjoerg Cremer, Peter Ruef
Heilbronn, Germany
Author Affiliations: Children's Hospital Heilbronn (Schneider M, Cremer H, Ruef P); Hospital Heilbronn, 74074 Heilbronn, Germany (Reimer A)
Corresponding Author: Markus Schneider, MD, SLK-Klinikum am Gesundbrunnen, Klinik f¨¹r Kinder- & Jugendmedizin/Perinatalzentrum Heilbronn, Am Gesundbrunnen 20-26, Germany (Tel: +49-7131-49-3702; Fax: +49-7131-49-3709; Email: markus.schneider@slk-kliniken.de)
doi: 10.1007/s12519-014-0509-6
Background: Systemic treatment with propranolol is proven to be effective for patients with hemangiomas with less side-effect. We used a propranolol gel for topical use on hemangiomas.
Methods: In this retrospective study, we analyzed 148 patients who had been treated topically with propranolol gel for 12 weeks. We analyzed the data of patients and clinically gave each hemangioma a "hemangioma score" to determine the treatment success.
Results: In 147 of the 148 patients, strong signs of resolution under treatment included lightening, paling, and less vascularization. The hemangioma score showed a significant decrease during the treatment. Relevant serum levels of propranolol were not found. Adverse effects were rare and not related to propranolol.
Conclusion: Topical treatment with propranolol gel is suitable for specific hemangiomas in addition to cryotherapy and systemic treatment with propranolol.
World J Pediatr 2014;10(4):313-317
Key words: hemangioma;
hemangioma score;
propranolol;
propranolol gel;
topical treatment
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