Quick Search
  Home Journal Information Current Issue Past Issues Services Contact Us  
Articles
Efficacy and safety of itraconazole use in infants 
 
Efficacy and safety of itraconazole use in infants
  Shuang Chen, Kai-Yi Sun, Xiao-Wei Feng, Xin Ran, Jebina Lama, Yu-Ping Ran
 [Abstract] [Full Text] [PDF]   Pageviews: 517 Times
 
Background:
Itraconazole has been used to treat fungal infections, in particular invasive fungal infections in infants or neonates in many countries.
Data sources:
Literature search was conducted through Ovid EMBASE, PubMed, ISI Web of Science, CNKI and Google scholarship using the following key words: ¡°pediatric¡± or ¡°infant¡± or ¡°neonate¡± and ¡°fungal infection¡± in combination with ¡°itraconazole¡±. Based on the literature and our clinical experience, we outline the administration of itraconazole in infants in order to develop evidence-based pharmacotherapy.
Results:
Of 45 articles on the use of itraconazole in infancy, 13 are related to superficial fungal infections including tinea capitis, sporotrichosis, mucosal fungal infections and opportunistic infections. The other 32 articles are related to systemic fungal infections including candidiasis, aspergillosis, histoplasmosis, zygomycosis, trichosporonosis and opportunistic infections as caused by Myceliophthora thermophila.
Conclusions:
Itraconazole is safe and effective at a dose of 5 mg/kg per day in a short duration of therapy for superficial fungal infections and 10 mg/kg per day for systemic fungal infections in infants. With a good compliance, it is cost-effective in treating infantile fungal infections. The profiles of adverse events induced by itraconazole in infants are similar to those in adults and children.
 
Key words: infant; itraconazole; prophylaxis; superficial fungal infections; systemic fungal infections
 
  [Articles Comment]

  title Author The End Revert Time Revert / Count

  Username:
  Comment Title: 
 
   
roger vivier bags 美女 美女

Home  |  Journal Information  |  Current Issue  |  Past Issues  |  Journal Information  |  Contact Us
Children's Hospital, Zhejiang University School of Medicine, China
Copyright 2007  www.wjpch.com  All Rights Reserved Designed by eb